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the antitumor effects of tranilast in lung cancer \[[@bib0010], [@bib0030], [@bib0055], [@bib0060], [@bib0065], [@bib0070], [@bib0075], [@bib0080], [@bib0085]\]. Thus, the amelioration of tranilast-mediated suppression of tumor angiogenesis may contribute to the potent antitumor effects of tranilast in lung cancer.

In the present study, we treated mice bearing established tumors with oral gavage of tranilast daily for 10 days, and we observed that oral administration of tranilast significantly suppressed tumor growth, as compared with untreated mice. Tranilast treatment with a single dose of 100 mg/kg reduced the tumor growth rate by ∼51% at day 14 after tumor cell inoculation. These results are consistent with the results of previous reports \[[@bib0055], [@bib0060], [@bib0065], [@bib0070], [@bib0075], [@bib0080]\]. In this study, we used a double-blinded design to analyze treatment effects and compared tumors from tranilast-treated and control mice at day 14 after tumor cell inoculation. We found that tumors from the tranilast group were significantly smaller than those from the control group. These results indicate that the antitumor activity of tranilast may not be primarily attributable to its immunosuppressive effects, as this effect was observed even in immunocompetent mice \[[@bib0070], [@bib0080], [@bib0085]\]. Tranilast, which has been proven to be safe for long-term use, is generally considered a safe drug \[[@bib0050], [@bib0055], [@bib0060], [@bib0065], [@bib0070], [@bib0080], [@bib0085]\]. Therefore, it would be beneficial for patients to be treated with tranilast for tumor control in the early stages of disease rather than during the advanced stages of disease.

It is well known that lung cancer is characterized by high rates of angiogenesis, which contributes to tumor growth
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