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To request a subscription to Thinking Electronics just email your request to newsletter@thinkingelectronics.com.au.Inhibition of rat adipocytes by corticosteroids.
The effect of corticosteroids on lipolysis of rat adipocytes incubated in vitro was investigated with a closed system in which cell free medium was exchanged for fresh medium every 2 h during a 72 h incubation period. Dexamethasone (0.1, 1, 5.0 and 10.0 microM) increased glucose consumption in a dose dependent manner. The stimulatory action of dexamethasone was abolished by cycloheximide, indicating an involvement of protein synthesis in the effect. Basal and isoproterenol stimulated glycerol release were decreased by 1.0 and 5.0 microM dexamethasone and by 0.1 and 1.0 microM corticosterone. However, 10.0 microM dexamethasone, 10.0 microM corticosterone or 0.1 microM corticosterone significantly increased basal glycerol release. The stimulatory action of dexamethasone on glycerol release was abolished by 0.01 microM actinomycin D. The results show that the inhibitory action of corticosteroids on lipolysis is mediated by protein synthesis and may be interpreted as a regulatory mechanism to attenuate excessive lipolysis in the intact adipocyte.[Vasodilatory effect of a new antidepressant drug on the isolated femoral artery of the rat (author’s transl)].
The vasodilatory effect of a new antidepressant drug (Fluoxetine) on isolated femoral arteries from normotensive rats (Wistar) and spontaneously hypertensive rats (SHR) was studied. Fluoxetine induced a dose-dependent potent vasodilation in both groups of rats. The direct effect on the vascular smooth muscle was assessed. Its dose-response curve was similar in both groups of rats, with a
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Name:
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File size:
16 MB
File type:
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Year:
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Language:
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Optimal way to store files in a database
I have a SQL Server database that I use as a file repository (similar to Microsoft Access). I am wondering what the best way to store and access these files is?
My current schema stores each file as a row in a table, where a file’s primary key is the file ID. This means that to find a row for a given file, I have to perform a table scan.
I could:
Store the files as BLOBs, but this means each file requires at least 4KB to store (8 if encoded). To get the file, you’ll have to use a SELECT *. This won’t be a problem for small files, but for large files, you’ll have to wait for the server to fetch the entire file.
Store the files in a more-complex table, such as a text file and some other columns. This seems overkill for a database storing files.
Store the files in some other filesystem, such as UNC paths. I would still have to do a separate SELECT on the UNC path of the file.
I’ve been thinking that this problem probably won’t have a really good solution. It seems that the best solution is going to be some compromise of one of the above (or maybe some third way). I’d like to get some feedback about how you would handle this problem.
A:
Just use a file server. SQL Server Express will work fine. If you don’t like SQLExpress, any Express edition of the full SQL Server is suitable for use as a file server.
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