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Neopterin is a natural killer-cell derived immunoregulatory peptide that can be elevated in bacterial and viral infections, graft-versus-host disease (GvHD), and different types of autoimmune disorders. A number of studies have suggested the clinical use of neopterin as an indicator of activated cell-mediated immunity in the presence of an impaired state of the immunoregulation. For example, in the presence of severe bacterial infections or in a state of severe GvHD the concentrations of neopterin are significantly higher than normal. In contrast, in the presence of certain types of cancer or other diseases the levels of neopterin are consistently normal. Up to the present, there is insufficient evidence that neopterin levels are related to the activity of malignant disease, to the existence of certain types of malignant disease, or to the prognosis of specific types of malignant disease. Further research is needed to elucidate the role of neopterin as a biochemical marker in the diagnosis and treatment of patients with different types of cancer and malignant diseases.
474 So.2d 1094 (1985)
Ex parte Saul DAVIS.
(In re Saul Davis v. State).
84-829.
Supreme Court of Alabama.
June 28, 1985.
Rehearing Denied July 19, 1985.
J. Knox Argo, Montgomery, for petitioner.
Charles A. Graddick, Atty. Gen., and Rivard Melson, Asst. Atty. Gen., for respondent.
JONES, Justice.
We granted certiorari to review the Court
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